Adsorption behaviour of several supports in reversed-phase thin-layer chromatography as demonstrated by the determination of relative partition coefficients of some 4-hydroxycoumarin derivatives

The adsorptive behaviour of four supports in reversed-phase thin-layer chromatography was investigated. Oleyl alcohol was used as the stationary phase and methanol-water mixtures as the mobile phase. A series of 4-hydroxycoumarins were used as test compounds. Kieselguhr and cellulose show adsorption...

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Bibliographic Details
Published in:Journal of Chromatography A 1982-01, Vol.237 (2), p.199-213
Main Authors: Van der Giesen, Willem F., Janssen, Lambert H.M.
Format: Article
Language:English
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Summary:The adsorptive behaviour of four supports in reversed-phase thin-layer chromatography was investigated. Oleyl alcohol was used as the stationary phase and methanol-water mixtures as the mobile phase. A series of 4-hydroxycoumarins were used as test compounds. Kieselguhr and cellulose show adsorption. Kieselgel also is not a good support, probably because of its large specific surface area. Kieselguhr modified by silanization behaves as a support without adsorptive sites. The R M values obtained with silanized Kieselguhr as the support correlate very well with the partition coefficients for the octanol-water system.
ISSN:0021-9673
DOI:10.1016/S0021-9673(00)83227-6