Capabilities of on-line element-specific detection in high-performance liquid chromatography using an inductively coupled argon plasma emission source detector

The applicability of the inductively coupled argon plasma (ICAP) as a detector in high-performance liquid chromatography (HPLC) was investigated. The influence of the flow-rate and the nature of the mobile phase on the operation of the ICAP source, and on peak broadening, sensitivity, linearity and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Chromatography A 1979-12, Vol.185, p.549-561
Main Authors: Gast, C.H., Kraak, J.C., Poppe, H., Maessen, F.J.M.J.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The applicability of the inductively coupled argon plasma (ICAP) as a detector in high-performance liquid chromatography (HPLC) was investigated. The influence of the flow-rate and the nature of the mobile phase on the operation of the ICAP source, and on peak broadening, sensitivity, linearity and detection limits was determined. At the flow-rates and mobile phase compositions normally applied in reversed-phase chromatography the ICAP proved to be a higly valuable HPLC detector. In straight-phase chromatography troublesome limitations in the choice of the mobile phase were observed. Peak broadening effects are acceptable; detection limits are in the nanograms per millilitre range while the linear range covers about four orders of magnitude. The sensitivity is essentially independent of the molecular form. The usefulness of ICAP—HPLC is illustrated by the separation of iron carbonyl and molybdenum carbonyl complexes and of ferrocene, organoarsenic, organomercury and organolead compounds.
ISSN:0021-9673
DOI:10.1016/S0021-9673(00)85629-0