Reversed-phase high-performance liquid chromatographic separation of saccharin, caffeine and benzoic acid using non-linear programming

A method is described which allows a chromatographic assay to be optimized with respect to the time needed to complete an analysis, while maintaining good resolution. The method introduces an operational research technique called nonlinear programming. It was used to optimize the eluent composition...

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Bibliographic Details
Published in:Journal of Chromatography A 1982-10, Vol.247 (2), p.221-229
Main Authors: Weyland, J.W., Rolink, H., Doornbos, D.A.
Format: Article
Language:English
Subjects:
food additives
food composition
food quality
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Summary:A method is described which allows a chromatographic assay to be optimized with respect to the time needed to complete an analysis, while maintaining good resolution. The method introduces an operational research technique called nonlinear programming. It was used to optimize the eluent composition for the essay of saccharin, caffeine and benzoic acid and resulted in a significant reduction in the analysis time.
ISSN:0021-9673
DOI:10.1016/S0021-9673(00)85945-2