High-performance liquid chromatography systems for the separation of benzodiazepines and their metabolites

The high-performance liquid chromatographic (HPLC) retention characteristics of 21 benzodiazepine drugs and some of their metabolites have been examined on both silica and ODS-silica packing materials. Four HPLC systems have been considered and retention data are presented for the drugs on these sys...

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Bibliographic Details
Published in:Journal of Chromatography A 1986, Vol.356 (1), p.37-46
Main Authors: Gill, R., Law, B., Gibbs, J.P.
Format: Article
Language:English
Subjects:
Analysis
Applied sciences
Biological and medical sciences
Exact sciences and technology
General pharmacology
Medical sciences
Other techniques and industries
Pharmacology. Drug treatments
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Summary:The high-performance liquid chromatographic (HPLC) retention characteristics of 21 benzodiazepine drugs and some of their metabolites have been examined on both silica and ODS-silica packing materials. Four HPLC systems have been considered and retention data are presented for the drugs on these systems. The correlation of retention data on the systems is considered with reference to the problem of identifying unknown benzodiazepines.
ISSN:0021-9673
DOI:10.1016/S0021-9673(00)91465-1