Gas chromatographic and gas chromatographic—mass spectrometric analysis of organic acids in plasma of patients with chronic renal failure

Apart from increased concentrations of aliphatic dicarboxylic acids and phenolic aromatic acids in plasma from patients with chronic renal failure, there is large elevation of a furanoid acid, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and of hippuric acid. The levels of 3-hydroxy- and 4-hyd...

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Bibliographic Details
Published in:Journal of Chromatography A 1984-04, Vol.289, p.259-266
Main Authors: Liebich, H.M., Pickert, A., Tetschner, B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Renal failure
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Summary:Apart from increased concentrations of aliphatic dicarboxylic acids and phenolic aromatic acids in plasma from patients with chronic renal failure, there is large elevation of a furanoid acid, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and of hippuric acid. The levels of 3-hydroxy- and 4-hydroxyhippuric acid are also raised. The quantitative results are as follows: furanoid acid in hemodialysis patients, 1.4 ± 0.6 mg/dl; in healthy individuals, 0.2 ± 0.1 mg/dl; hippuric acid in hemodialysis patients, 9.8 ± 6.5 mg/dl; in healthy individuals, 0.4 ± 0.5 mg/dl. Both compounds are dialysable, but less effectively than creatinine and urea. The mean elimination rate of the furanoid acid is only 21%.
ISSN:0021-9673
DOI:10.1016/S0021-9673(00)95093-3