Capillary column gas chromatography—mass spectrometry and gas chromatography—tandem mass spectrometry detection of chemical warfare agents in a complex airborne matrix

The chemical warfare agents sarin, soman and mustard were detected and confirmed during full-scanning gas chromatography (GC)—mass spectrometry (MS) at the nanogram level in spiked extracts of a diesel exhaust environment sampled onto the charcoal of a Canadian C2 respirator canister. This matrix, t...

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Bibliographic Details
Published in:Journal of Chromatography A 1990, Vol.504, p.259-268
Main Authors: D'Agostino, P.A., Provost, L.R., Anacleto, J.F., Brooks, P.W.
Format: Article
Language:English
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Summary:The chemical warfare agents sarin, soman and mustard were detected and confirmed during full-scanning gas chromatography (GC)—mass spectrometry (MS) at the nanogram level in spiked extracts of a diesel exhaust environment sampled onto the charcoal of a Canadian C2 respirator canister. This matrix, typical of what might be expected under battlefield conditions, was used for the development of a GCMSMS method for the verification of trace levels of sarin, soman and mustard. Chemical interferences associated with this complex sample were virtually eliminated and low-picogram GCMSMS detection limits were estimated for these chemical warfare agents in the presence of numerous interfering diesel exhaust and charcoal bed components.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)89531-5