Determination of the anticancer drug bruceoside-A in the Chinese drug Yadanzi ( Brucea Javanica Merr.)

A high-performance liquid chromatographic method was developed for the determination of bruceoside-A in the Chinese drug Yadanzi ( Brucea javanica Merr). After being boiled in ethanol for the lysis of enzyme, nuts of the fruits of Yadanzi were ground and refluxed with light petroleum (b.p. 60–90°C)...

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Bibliographic Details
Published in:Journal of Chromatography A 1991, Vol.543 (1), p.250-256
Main Authors: Chi, Hua, Wang, Yun-Ping, Zhou, Tong-Hui, Jin, Chun-Lian
Format: Article
Language:English
Subjects:
antineoplastic agents
Brucea javanica
determination
fruits
high performance liquid chromatography
nuts
plant extracts
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Summary:A high-performance liquid chromatographic method was developed for the determination of bruceoside-A in the Chinese drug Yadanzi ( Brucea javanica Merr). After being boiled in ethanol for the lysis of enzyme, nuts of the fruits of Yadanzi were ground and refluxed with light petroleum (b.p. 60–90°C) to remove the oil, then sonicated in methanol for 1 h and the methanolic solutionw as left overnight. The resulting solution was analysed using a high-performance liquid chromatograph equipped with a reversed-phase ODS-bonded column and eluted with methanol—water (41:59, v/v) at a flow-rate of 1 ml/min with UV detection at 254 nm.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)95776-0