Synthesis of 2-trifluoromethoxyethyl trifluoromethoxyacetate and derived 2-trifluoromethoxyacrylates

Graphic The synthesis of 2-trifluoromethoxyethyl trifluoromethoxyacetate 2 by oxidation of bis(2-trifluoromethoxyethyl)ether 1 followed by its anionic condensation with aldehydes, ketones and immonium salts under mild conditions, and further dehydration or deamination, enabled the preparation of 3-a...

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Bibliographic Details
Published in:Journal of fluorine chemistry 2002-10, Vol.117 (2), p.161-166
Main Authors: Blazejewski, Jean-Claude, Anselmi, Elsa, Wernicke, Angelika, Wakselman, Claude
Format: Article
Language:English
Subjects:
Acrylates
Aldehydes
Eschenmoser salt
Ester condensation
Ether oxidation
Ketones
Trifluoromethoxy group
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Summary:Graphic The synthesis of 2-trifluoromethoxyethyl trifluoromethoxyacetate 2 by oxidation of bis(2-trifluoromethoxyethyl)ether 1 followed by its anionic condensation with aldehydes, ketones and immonium salts under mild conditions, and further dehydration or deamination, enabled the preparation of 3-aryl and 3-alkyl-2-trifluoromethoxacrylates 8a– e as well as the parent 2-trifluoromethoxyacrylate 8f.
ISSN:0022-1139
1873-3328
DOI:10.1016/S0022-1139(02)00152-5