Reaction of halothane with carbonyl compounds in the presence of bases

Graphic The reaction of halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane ( 1), with aldehydes and ketones in the presence of bases was found to give 1-alkyl- or 1-aryl-2-bromo-2-chloro-3,3,3-trifluoropropanols ( 2) or 2-chloro-3,3-difluoro-2-propenols ( 3) selectively in good to moderate yields dep...

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Bibliographic Details
Published in:Journal of fluorine chemistry 2003-10, Vol.123 (2), p.283-285
Main Authors: Ando, Akira, Takahashi, Junko, Nakamura, Yuki, Maruyama, Naoki, Nishihara, Masakazu, Fukushima, Kaori, Moronaga, Jin, Inoue, Mayumi, Sato, Kazuyuki, Omote, Masaaki, Kumadaki, Itsumaro
Format: Article
Language:English
Subjects:
Butyllithium
Carbonyl compounds
Fluorine
Halothane
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Summary:Graphic The reaction of halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane ( 1), with aldehydes and ketones in the presence of bases was found to give 1-alkyl- or 1-aryl-2-bromo-2-chloro-3,3,3-trifluoropropanols ( 2) or 2-chloro-3,3-difluoro-2-propenols ( 3) selectively in good to moderate yields depending on the bases and reaction conditions.
ISSN:0022-1139
1873-3328
DOI:10.1016/S0022-1139(03)00148-9