Ruthenium-catalyzed intramolecular hydroamination of aminoalkynes

Low-valent ruthenium complexes with a π-acidic ligand, such as Ru(η 6-cot)(dmfm) 2 [cot=1,3,5-cyclooctatriene, dmfm=dimethyl fumarate] and Ru 3(CO) 12, showed high catalytic activity for the intramolecular hydroamination of aminoalkynes. The reaction is highly regioselective, in which a nitrogen ato...

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Bibliographic Details
Published in:Journal of organometallic chemistry 2001-03, Vol.622 (1), p.149-154
Main Authors: Kondo, Teruyuki, Okada, Takumi, Suzuki, Toshiaki, Mitsudo, Take-aki
Format: Article
Language:English
Subjects:
Aminoalkynes
Cyclization
Hydroamination
Ruthenium catalyst
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Summary:Low-valent ruthenium complexes with a π-acidic ligand, such as Ru(η 6-cot)(dmfm) 2 [cot=1,3,5-cyclooctatriene, dmfm=dimethyl fumarate] and Ru 3(CO) 12, showed high catalytic activity for the intramolecular hydroamination of aminoalkynes. The reaction is highly regioselective, in which a nitrogen atom is selectively attached to an internal carbon of alkynes to give five-, six-, and seven-membered nitrogen heterocycles as well as indoles in good to high yields.
ISSN:0022-328X
1872-8561
DOI:10.1016/S0022-328X(00)00869-X