1H-, 13C-, and 15N-NMR and ESI-TOF + MS studies of a supramolecular complex of silver(I) and a cholaphane

A novel application of the mixed anhydride procedure for synthesising lithocholic acid piperazine diamide, an important intermediate in designing bile acid-based supramolecular host molecules, is reported. The synthesis of a thiophene-containing cholaphane with transition metal complexation ability...

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Bibliographic Details
Published in:Journal of organometallic chemistry 2003-02, Vol.668 (1), p.43-50
Main Authors: Virtanen, Elina, Koivukorpi, Juha, Tamminen, Jari, Mänttäri, Pia, Kolehmainen, Erkki
Format: Article
Language:English
Subjects:
Ag(I) complexation
Cholaphane
ESI-TOF + MS
Multinuclear magnetic resonance
Piperazine
Thiophene
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Summary:A novel application of the mixed anhydride procedure for synthesising lithocholic acid piperazine diamide, an important intermediate in designing bile acid-based supramolecular host molecules, is reported. The synthesis of a thiophene-containing cholaphane with transition metal complexation ability and 1H-, 13C-, and 15N-NMR as well as ESI-TOF + MS spectral characterisation of the ligand and its Ag(I) complex are included. The coordination of the Ag(I) ion as well as an ability of the cholaphane to recognise Ag(I) ion over alkali metal ions, especially potassium ion, is discussed. The possible medical applications are also presented. Synthesis, spectral characterisation, and an ability of a cholaphane to recognise Ag(I) ion over alkali metal ions is presented. The possible medical applications are also discussed.
ISSN:0022-328X
1872-8561
DOI:10.1016/S0022-328X(02)02096-X