Novel metallocenic compounds as antimalarial agents. Study of the position of ferrocene in chloroquine

The synthesis, characterization and antimalarial activity of two new ferrocene–chloroquine compounds are reported. One of them, 7-chloro-4- N-[(4- N′-ethyl- N′-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartrate ( 2) showed very promising antimalarial activity in vivo on mice infe...

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Bibliographic Details
Published in:Journal of organometallic chemistry 1999-10, Vol.589 (1), p.59-65
Main Authors: Biot, C, Delhaes, L, Abessolo, H, Domarle, O, Maciejewski, L.A, Mortuaire, M, Delcourt, P, Deloron, P, Camus, D, Dive, D, Brocard, J.S
Format: Article
Language:English
Subjects:
Antimalarial agents
Chloroquine
Ferrocene
Metallocenes
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Summary:The synthesis, characterization and antimalarial activity of two new ferrocene–chloroquine compounds are reported. One of them, 7-chloro-4- N-[(4- N′-ethyl- N′-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartrate ( 2) showed very promising antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and in vitro against chloroquine resistant-strains of Plasmodium falciparum.
ISSN:0022-328X
1872-8561
DOI:10.1016/S0022-328X(99)00302-2