Enhanced Renal Toxicity by Inorganic Mercury in Metallothionein-Null Mice

To elucidate a protective role of metallothionein (MT) in the manifestation of inorganic mercury toxicity, we studied the susceptibility of MT-null mice to the renal toxicity of mercuric chloride. Because the MT-null (J) mice are a genetic background of 129/Sv strain, the 129/Sv mice were used as wi...

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Bibliographic Details
Published in:The Journal of pharmacology and experimental therapeutics 1997-12, Vol.283 (3), p.1529-1533
Main Authors: Satoh, Masahiko, Nishimura, Noriko, Kanayama, Yoshitaka, Naganuma, Akira, Suzuki, Tsuguyoshi, Tohyama, Chiharu
Format: Article
Language:English
Subjects:
Animals
blood urea nitrogen
BUN
Kidney - drug effects
Male
Mercury - toxicity
metallothionein
Metallothionein - genetics
Metallothionein - physiology
metallothionein-I and -II knock-out mice
Mice
Mice, Inbred C57BL
Mice, Knockout
MT-null mice
National Institute for Environmental Studies
NIES
nonprotein SH
NP-SH
γ-glutamyltranspeptidase
γ-GTP
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Summary:To elucidate a protective role of metallothionein (MT) in the manifestation of inorganic mercury toxicity, we studied the susceptibility of MT-null mice to the renal toxicity of mercuric chloride. Because the MT-null (J) mice are a genetic background of 129/Sv strain, the 129/Sv mice were used as wild-type controls. Nine-week-old male MT-null (J) and 129/Sv mice were given subcutaneous injections of mercuric chloride at doses of 10 to 40 μmol/kg. The basal MT level in the kidney of MT-null (J) mice was undetectable (
ISSN:0022-3565
1521-0103
DOI:10.1016/S0022-3565(24)37175-7