An evaluation of a dentifrice containing salivary peroxidase elements for the control of gingival disease in patients with irradiated head and neck cancer

Patients who have undergone irradiation for head and neck tumors commonly have xerostomia. Loss of the protective constituents normally found in saliva leaves patients at greater risk for development of significant dental pathologic disorders, including gingival and periodontal disease. Periodontal...

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Bibliographic Details
Published in:The Journal of prosthetic dentistry 1996-09, Vol.76 (3), p.292-296
Main Authors: Toljanic, Joseph A, Siddiqui, Azfar A, Patterson, Garnet L, Irwin, Mark E
Format: Article
Language:English
Subjects:
Cranial Irradiation - adverse effects
Cross-Over Studies
Dental Plaque - etiology
Dental Plaque - prevention & control
Dental Plaque Index
Dentifrices - chemistry
Dentifrices - therapeutic use
Double-Blind Method
Female
Gingival Diseases - etiology
Gingival Diseases - prevention & control
Head and Neck Neoplasms - radiotherapy
Humans
Male
Patient Compliance
Periodontal Index
Peroxidases - therapeutic use
Saliva - enzymology
Salivary Proteins and Peptides - therapeutic use
Treatment Outcome
Xerostomia - complications
Xerostomia - etiology
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Summary:Patients who have undergone irradiation for head and neck tumors commonly have xerostomia. Loss of the protective constituents normally found in saliva leaves patients at greater risk for development of significant dental pathologic disorders, including gingival and periodontal disease. Periodontal disease and tooth extractions are currently accepted as etiologic factors for the development of osteoradionecrosis. This double-blind crossover trial was conducted to assess the efficacy of a dentifrice containing salivary peroxidase elements in the reduction of gingivitis in a population of patients with irradiated cancer. Subjects were instructed to brush with the dentifrice provided. Plaque and gingival index values were obtained and statistically compared with baseline values. A weak positive effect was found between use of the dentifrice and a reduction in gingival inflammation. Patient compliance was a limiting factor in this treatment effect. The results suggest possible efficacy for the dentifrice in augmenting traditional measures of postradiation oral health maintenance.
ISSN:0022-3913
1097-6841
DOI:10.1016/S0022-3913(96)90174-2