Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees

Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consistin...

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Bibliographic Details
Published in:Journal of psychiatric research 1998-09, Vol.32 (5), p.255-259
Main Authors: Franchini, Linda, Serretti, Alessandro, Gasperini, Mariangela, Smeraldi, Enrico
Format: Article
Language:English
Subjects:
Adult
Antidepressant response
Antidepressive Agents, Second-Generation - adverse effects
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - drug therapy
Bipolar Disorder - genetics
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - genetics
Female
Fluvoxamine - adverse effects
Fluvoxamine - therapeutic use
Genetic Predisposition to Disease - genetics
Humans
Male
Medical sciences
Middle Aged
Mood disorder
Morbidity risk
Neuropharmacology
Pedigree
Pharmacogenetics
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Treatment Outcome
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Summary:Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.
ISSN:0022-3956
1879-1379
DOI:10.1016/S0022-3956(98)00004-1