Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test

• Published in: Life sciences (1973) 2002-02, Vol.70 (14), p.1669-1676
• Main Authors: Torres-López, Jorge E, Ortiz, Mario I, Castañeda-Hernández, Gilberto, Alonso-López, Rosario, Asomoza-Espinosa, Raquel, Granados-Soto, Vinicio
• Format: Article
• Language: English
• Subjects: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Behavior, Animal - drug effects; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors - therapeutic use; Diclofenac; Diclofenac - therapeutic use; Female; Formaldehyde; Inflammation - chemically induced; Inflammation - physiopathology; Inflammatory pain; Pain - chemically induced; Pyrazoles; Rats; Rats, Wistar; Resveratrol; Stilbenes - therapeutic use; Sulfonamides - therapeutic use
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/S0024-3205(02)01491-1

The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) and diclofenac (non-selective COX inhibitor). Rats received local pretreatment with saline, celecoxib, diclofenac or resveratrol followed by 50 μl of either 1% or 5% formalin. Peripheral administration of celecoxib did not produce antinociception at either formalin concentration. In contrast, diclofenac and resveratrol produced a dose-dependent antinociceptive effect in the second phase of both 1% and 5% formalin test. The peripheral antinociception produced by diclofenac or resveratrol was due to a local action, as drug administration in the contralateral paw was ineffective. Results indicate that the selective COX-2 inhibitor celecoxib does not produce peripheral antinociception in formalin-induced inflammatory pain. In contrast, selective COX-1 and non-selective COX inhibitors (resveratrol and diclofenac, respectively) are effective drugs in this model of pain.