Analysis of the role of delta opioid receptors in gastroprotection in the rat

The effect of delta opioid agonists - [D-Ala 2, D-Leu 5]-enkephalin (DADLE), [D-Pen 2, D-Pen 5]-enkephalin (DPDPE) and deltorphin II - on acidified ethanol induced gastric mucosal lesions was studied in the rat compared with that of morphine. It was found that DADLE, DPDPE, deltorphin II and morphin...

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Bibliographic Details
Published in:Life sciences (1973) 1997, Vol.60 (16), p.1337-1347
Main Authors: Gyires, K., Rónai, A.Z., Tóth, G., Darula, Zs, Fürst, S.
Format: Article
Language:English
Subjects:
Analgesics - therapeutic use
Animals
Binding Sites
DADLE
deltorphin II
Dose-Response Relationship, Drug
DPDPE
Enkephalin, D-Penicillamine (2,5)
Enkephalin, Leucine-2-Alanine - therapeutic use
Enkephalins - therapeutic use
Ethanol - toxicity
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric Mucosa - ultrastructure
gastric mucosal lesions
Ileum - drug effects
Ileum - ultrastructure
Male
Mice
Mice, Inbred Strains
Morphine - therapeutic use
Muscle, Smooth - drug effects
Muscle, Smooth - ultrastructure
naltrindole
Oligopeptides - therapeutic use
Rats
Rats, Wistar
Receptors, Opioid, delta - agonists
Receptors, Opioid, delta - physiology
Receptors, Opioid, mu - physiology
Stomach - drug effects
Stomach - ultrastructure
Stomach Diseases - chemically induced
Stomach Diseases - prevention & control
Vas Deferens - drug effects
Vas Deferens - ultrastructure
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Summary:The effect of delta opioid agonists - [D-Ala 2, D-Leu 5]-enkephalin (DADLE), [D-Pen 2, D-Pen 5]-enkephalin (DPDPE) and deltorphin II - on acidified ethanol induced gastric mucosal lesions was studied in the rat compared with that of morphine. It was found that DADLE, DPDPE, deltorphin II and morphine exerted a dose-dependent inhibition on the mucosal lesions injected subcutaneously, their ID 50 values were 0.037, 1.8, 3.5 and 0.35 μmoles kg , respectively. Naltrindole (10 mg kg sc.), the selective delta opioid receptor antagonist, inhibited the gastroprotective effect of DADLE, DPDPE and deltorphin II, but it failed to antagonise the effect of morphine. Our results suggest that 1. delta receptors are involved in opioid-mediated gastroprotection, 2. ethanol-induced gastric mucosal damage in the rat may be a quick, simple in vivo model for screening opioid delta receptor agonists and antagonists in the periphery.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)00079-9