Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells

The direct gastric mucosal cellular effect of four PL-10 substances (a synthesized part of human body protection compound, BPC containing 14 or 15 amino acids) was studied on freshly isolated rat gastric mucosal cells and on a mouse myeloma cell line (Sp2/0-Ag14) in an ethanol-induced cell injury mo...

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Bibliographic Details
Published in:Life sciences (1973) 1997, Vol.61 (16), p.PL243-PL248
Main Authors: Bódis, Beáta, Karádi, Oszkár, Németh, Péter, Dohoczky, Csaba, Kolega, Marko, Mózsik, Gyula
Format: Article
Language:English
Subjects:
Animals
body protection compound
Cell Survival
Cytoprotection
direct cytoprotection
Ethanol - toxicity
Gastric Mucosa - drug effects
Humans
isolated rat gastric mucosal cells
Mice
Multiple Myeloma
Peptide Fragments - pharmacology
PL-10 substances
Proteins - pharmacology
Rats
Succinate Dehydrogenase - metabolism
Trypan Blue
Tumor Cells, Cultured
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Summary:The direct gastric mucosal cellular effect of four PL-10 substances (a synthesized part of human body protection compound, BPC containing 14 or 15 amino acids) was studied on freshly isolated rat gastric mucosal cells and on a mouse myeloma cell line (Sp2/0-Ag14) in an ethanol-induced cell injury model. The examined substances were not toxic for the cells. Two of them proved to be significantly protective against the direct cellular damaging effect of ethanol (PL 10.1.15AK-3 in 5 μg ml dose and PL 10.1.AK14-2 dose-dependently, ED 50 = 50 ng ml ) on gastric mucosal cells. This cytoprotective effect was failured on mouse myeloma cells. Based on these results a part of the in vivo protection induced by BPC seems to be a direct cellular protective effect to gastric mucosal cells.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)00744-3