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Long-term rectal administration of enzyme mixture containing papain, trypsin and chymotrypsin in the same ratio as the preparation Wobe-Mugos E (Mucos Pharma, Germany) was evaluated for their antitumor effects in C 57B1 6 inbred mice inoculated with B1 6 melanoma cells. 30% of animals in the test gr...

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Published in:Life sciences (1973) 1997-12, Vol.62 (3), p.PL/43-PL/48
Main Authors: Wald, M., Zavadova, E., Poučková, P., Zadinová, M., Boubelík, M.
Format: Article
Language:English
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Summary:Long-term rectal administration of enzyme mixture containing papain, trypsin and chymotrypsin in the same ratio as the preparation Wobe-Mugos E (Mucos Pharma, Germany) was evaluated for their antitumor effects in C 57B1 6 inbred mice inoculated with B1 6 melanoma cells. 30% of animals in the test group (3 pcs) have been cured of cancer. In the rest of animals (70%) the survival time was prolonged by 58.3% compared to the control group (from average survival time of 24 days in control group to 38 days in the test group). Based on histological and immunohistochemical evaluation a faster process of metastasizing was found in control group than in the group treated with the polyenzyme preparation. In the case of melanoma B1 6 an antimetastatic effect of the preparation was thus proved. © 1997 Elsevier Science Inc.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)01106-5