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Long-term rectal administration of enzyme mixture containing papain, trypsin and chymotrypsin in the same ratio as the preparation Wobe-Mugos E (Mucos Pharma, Germany) was evaluated for their antitumor effects in C 57B1 6 inbred mice inoculated with B1 6 melanoma cells. 30% of animals in the test gr...
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Published in: | Life sciences (1973) 1997-12, Vol.62 (3), p.PL/43-PL/48 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Long-term rectal administration of enzyme mixture containing papain, trypsin and chymotrypsin in the same ratio as the preparation Wobe-Mugos E (Mucos Pharma, Germany) was evaluated for their antitumor effects in C
57B1
6 inbred mice inoculated with B1
6 melanoma cells. 30% of animals in the test group (3 pcs) have been cured of cancer. In the rest of animals (70%) the survival time was prolonged by 58.3% compared to the control group (from average survival time of 24 days in control group to 38 days in the test group). Based on histological and immunohistochemical evaluation a faster process of metastasizing was found in control group than in the group treated with the polyenzyme preparation. In the case of melanoma B1
6 an antimetastatic effect of the preparation was thus proved. © 1997 Elsevier Science Inc. |
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ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/S0024-3205(97)01106-5 |