Protective effect of stobadine in experimental colitis

To assess the possible role of reactive oxygen species in inflammatory bowel disease, the effect of the antioxidant and free radical scavenger stobadine was studied in acetic acid-induced experimental colitis. Stobadine administered locally into the colon was found to reduce the extent of colonic mu...

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Bibliographic Details
Published in:Life sciences (1973) 1999-10, Vol.65 (18), p.1919-1921
Main Authors: Nosál'ová, Viera, Bauer, Viktor
Format: Article
Language:English
Subjects:
Acetic Acid
Animals
Antioxidants - therapeutic use
Carbolines - therapeutic use
colitis
Colitis - chemically induced
Colitis - pathology
Colitis - prevention & control
Free Radical Scavengers - therapeutic use
Gastrointestinal Hemorrhage - chemically induced
Gastrointestinal Hemorrhage - pathology
Gastrointestinal Hemorrhage - prevention & control
Glutathione - metabolism
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Male
rat
Rats
Rats, Wistar
reactive oxygen species
stobadine
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Summary:To assess the possible role of reactive oxygen species in inflammatory bowel disease, the effect of the antioxidant and free radical scavenger stobadine was studied in acetic acid-induced experimental colitis. Stobadine administered locally into the colon was found to reduce the extent of colonic mucosal injury, abolish the increase in myeloperoxidase activity, attenuate the enhanced vascular permeability, and prevent the depletion of reduced glutathione. The attempt to reduce pharmacologically excessive free radical production and oxidative damage in the inflamed colonic mucosa may be regarded as a complementary treatment of ulcerative colitis.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(99)00447-6