Mucolytics and antioxidant activity

We investigated effects of the mucolytics ambroxol and N-acetylcysteine on airways reactivity evoked by histamine in guinea pigs exposed to toluene vapors. We did not find significant changes in reactivity of tracheal smooth muscle from animals treated with mucolytics compared to the control group....

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Bibliographic Details
Published in:Life sciences (1973) 1999-10, Vol.65 (18), p.1923-1925
Main Authors: Strapková, Anna, Nosál'ová, Gabriela, Fraňová, Soňa
Format: Article
Language:English
Subjects:
Acetylcysteine - administration & dosage
Acetylcysteine - therapeutic use
airway hyperreactivity
ambroxol
Ambroxol - administration & dosage
Ambroxol - therapeutic use
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Expectorants - administration & dosage
Expectorants - pharmacology
Expectorants - therapeutic use
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - therapeutic use
Guinea Pigs
Histamine Release - drug effects
Injections, Intraperitoneal
Lung - drug effects
Lung - metabolism
Male
Muscle, Smooth - drug effects
Muscle, Smooth - metabolism
N-acetylcysteine
Respiratory Tract Diseases - chemically induced
Respiratory Tract Diseases - prevention & control
Toluene
Trachea - drug effects
Trachea - metabolism
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Summary:We investigated effects of the mucolytics ambroxol and N-acetylcysteine on airways reactivity evoked by histamine in guinea pigs exposed to toluene vapors. We did not find significant changes in reactivity of tracheal smooth muscle from animals treated with mucolytics compared to the control group. However, the administration of ambroxol and N-acetylcysteine caused a significant decrease in lung tissue reactivity. The effect of ambroxol was more pronounced after intraperitoneal injection than after inhalation, while N-acetylcysteine was only effective after inhalation. The protective effects of mucolytics in the lung tissue may be due to their antioxidant activity together with other mechanisms.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(99)00448-8