Ceftriaxone-induced symptomatic pseudolithiasis mimicking ICP elevation

In neurosurgery, ceftriaxone is a widely used, third generation cephalosporin for the treatment of CNS infections and perioperational prophylaxis. Recent studies have demonstrated that ceftriaxone induces reversible precipitates in the gallbladder. This complication is referred to as “biliary pseudo...

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Bibliographic Details
Published in:Neuro-chirurgie 2006-02, Vol.52 (1), p.71-71
Main Authors: Evliyaoglu, C., Kizartici, T., Bademci, G., Unal, B., Keskil, S.
Format: Article
Language:English
Subjects:
antibiotic prophylaxis
Cephalosporin
children
surgery
Online Access:Get full text
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Summary:In neurosurgery, ceftriaxone is a widely used, third generation cephalosporin for the treatment of CNS infections and perioperational prophylaxis. Recent studies have demonstrated that ceftriaxone induces reversible precipitates in the gallbladder. This complication is referred to as “biliary pseudolithiasis”, and it has symptoms similar to the raised intracranial pressure (ICP) symptoms of the perioperative period. Symptomatic biliary pseudolithiasis should be kept in mind in all pediatric neurosurgery cases under ceftriaxone therapy in order to prevent unnecessary postoperative investigations and surgery.
ISSN:0028-3770
1773-0619
DOI:10.1016/S0028-3770(06)71185-7