Probabilistic learning and reversal deficits in patients with Parkinson’s disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication

Three groups of patients with Parkinson’s disease (PD) — mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) — and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-p...

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Bibliographic Details
Published in:Neuropsychologia 2000-01, Vol.38 (5), p.596-612
Main Authors: Swainson, R., Rogers, R.D., Sahakian, B.J., Summers, B.A., Polkey, C.E., Robbins, T.W.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antiparkinson Agents - adverse effects
Antiparkinson Agents - therapeutic use
Biological and medical sciences
Concurrent
Cortical
Discrimination (Psychology) - physiology
Dopamine
Epilepsy - surgery
Female
Frontal Lobe - physiology
Frontal Lobe - surgery
Humans
Learning Disorders - psychology
Levodopa - adverse effects
Levodopa - therapeutic use
Male
Medical sciences
Models, Statistical
Neostriatum - pathology
Organic mental disorders. Neuropsychology
Parkinson Disease - drug therapy
Parkinson Disease - psychology
Pattern Recognition, Visual - physiology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reversal Learning - physiology
Reward
Space Perception - physiology
Temporal Lobe - physiology
Temporal Lobe - surgery
Visual discrimination
Visual Perception - physiology
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Summary:Three groups of patients with Parkinson’s disease (PD) — mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) — and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses — based on disease severity and possible deleterious effects of medication — are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning.
ISSN:0028-3932
1873-3514
DOI:10.1016/S0028-3932(99)00103-7