Factors influencing detector matching in multidetector SEC: solvent and concentration effects

A study has been conducted on the origin of the molecular weight (MWT) dependence of the apparent interdetector-delay (IDD) in multidetector size exclusion chromatography (SEC). The IDD–MWT relationship proved to be independent of polymer concentration (for a given molecular weight). In contrast, th...

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Bibliographic Details
Published in:Polymer (Guilford) 1998-11, Vol.39 (23), p.5789-5798
Main Authors: Zammit, Michael D., Davis, Thomas P., Suddaby, Kevin G.
Format: Article
Language:English
Subjects:
Applied sciences
dead time
Exact sciences and technology
interdetector-delay
Organic polymers
Physicochemistry of polymers
poly(styrene)
Properties and characterization
Structure, morphology and analysis
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Summary:A study has been conducted on the origin of the molecular weight (MWT) dependence of the apparent interdetector-delay (IDD) in multidetector size exclusion chromatography (SEC). The IDD–MWT relationship proved to be independent of polymer concentration (for a given molecular weight). In contrast, the IDD–MWT relationship was found to be influenced by the polymer–solvent interaction, as shown by SEC experiments on polystyrene in a mixed tetrahydrofuran–water eluent. Confirmation of this discovery was provided by measured variations in the IDD–MWT relationship for polystyrene and poly(methyl methacrylate) in THF eluent. Possible reasons for the strong influence of the polymer–solvent interaction on the IDD are discussed in the paper.
ISSN:0032-3861
1873-2291
DOI:10.1016/S0032-3861(97)10373-1