Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidase

Glucose-sensitive hydrogels were prepared by the copolymerization of diethylaminoethyl methacrylate (DEAEM), poly(ethylene glycol) monomethacrylate (PEGMA) and functionalized glucose oxidase (GOD) and catalase in solution. Tetra(ethylene glycol) dimethacrylate (TEGDMA) was used as the crosslinking a...

Full description

Saved in:
Bibliographic Details
Published in:Polymer (Guilford) 2000-05, Vol.41 (11), p.3975-3983
Main Authors: Podual, K., Doyle, F.J., Peppas, N.A.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Cationic hydrogel
Equilibrium swelling
Exact sciences and technology
General pharmacology
Glucose-sensitivity
Medical sciences
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Solution and gel properties
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glucose-sensitive hydrogels were prepared by the copolymerization of diethylaminoethyl methacrylate (DEAEM), poly(ethylene glycol) monomethacrylate (PEGMA) and functionalized glucose oxidase (GOD) and catalase in solution. Tetra(ethylene glycol) dimethacrylate (TEGDMA) was used as the crosslinking agent. The equilibrium and dynamic swelling properties were studied to investigate the pH-sensitive swelling behavior of the gels. The effects of crosslinking ratio and enzyme content on the swelling properties were studied. The hydrogels demonstrated critical swelling behavior as the pH approached 7.0. The mesh sizes and the diffusion coefficients were determined. Dynamic swelling studies were performed and the results were analyzed using a first-order model to calculate the time constants of swelling and syneresis. Pulsatile swelling studies revealed the reversible nature of the swelling/deswelling process.
ISSN:0032-3861
1873-2291
DOI:10.1016/S0032-3861(99)00620-5