Supercritical antisolvent precipitation of salbutamol microparticles

The micronization of salbutamol has been tested by supercritical antisolvent precipitation to assess the possibility of producing microparticles with controlled particle size and distribution. Various liquid solvents have been used to find the solvent–solute couple suitable for optimum processing; s...

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Bibliographic Details
Published in:Powder technology 2001-01, Vol.114 (1), p.17-22
Main Authors: Reverchon, E, Della Porta, G, Pallado, P
Format: Article
Language:English
Subjects:
Aerosol
Biological and medical sciences
General pharmacology
Medical sciences
Microparticles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Salbutamol
Supercritical antisolvent
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Summary:The micronization of salbutamol has been tested by supercritical antisolvent precipitation to assess the possibility of producing microparticles with controlled particle size and distribution. Various liquid solvents have been used to find the solvent–solute couple suitable for optimum processing; supercritical CO 2 has been used as the antisolvent. Salbutamol was tested using dimethylsulphoxide (DMSO), methyl alcohol and ethanol–water mixtures. Only when DMSO was used, was obtained a successful micronization. Various morphologies were observed on varying the precipitation pressure. The influence of liquid solution concentration on the dimensions of salbutamol particles was studied. The most interesting morphology consisted of rod-like particles of controlled length between 1 and 3 μm and diameters between 0.2 and 0.35 μm; these particles were obtained operating at 40°C and in the pressure range between 100 and 150 bar.
ISSN:0032-5910
1873-328X
DOI:10.1016/S0032-5910(00)00257-6