Ventricular arrhythmogenic dose of adrenaline during sevoflurane, isoflurane, and halothane anaesthesia either with or without ketamine or thiopentone in cats

The doses of adrenaline required to induce ventricular arrhythmia during sevoflurane, isoflurane and halothane anaesthesia, either with or without infusions of ketamine (76 μg kg −1 min −1) or thiopentone (0·5 mg kg −1 min −1), were determined in cats. Groups of six to eight cats were maintained at...

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Bibliographic Details
Published in:Research in veterinary science 1996-03, Vol.60 (2), p.134-137
Main Authors: Hikasa, Y, Okabe, C, Takase, K, Ogasawara, S
Format: Article
Language:English
Subjects:
Anesthesia, General - veterinary
Anesthetics, Dissociative
Anesthetics, General
Anesthetics, Intravenous
Animals
Blood Pressure - drug effects
Cats
Diastole - drug effects
Epinephrine - pharmacology
Ethers
Female
Halothane
Isoflurane
Ketamine
Male
Methyl Ethers
Systole - drug effects
Thiopental
Tidal Volume
Ventricular Fibrillation - chemically induced
Ventricular Fibrillation - physiopathology
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Summary:The doses of adrenaline required to induce ventricular arrhythmia during sevoflurane, isoflurane and halothane anaesthesia, either with or without infusions of ketamine (76 μg kg −1 min −1) or thiopentone (0·5 mg kg −1 min −1), were determined in cats. Groups of six to eight cats were maintained at end-tidal concentrations equivalent to 1·25 times the minimal alveolar concentration of each anaesthetic. The mean dose of adrenaline required to induce arrhythmia during sevoflurane anaesthesia (19·0 μg kg −1) was approximately 11 times higher than that required during halothane anaesthesia (1·66 μg kg −1) and the same as that required during isoflurane anaesthesia (19·0 μg kg −1). Ketamine tended to decrease the requirement of adrenaline during halothane anaesthesia, but not significantly, and did not change the requirement during isoflurane or sevofturane anaesthesia. Thiopentone did not change the requirement for adrenaline during halothane, isoflurane or sevoflurane anaesthesia. It was concluded that either with or without ketamine or thiopentone, the effect of sevoflurane on the sensitisation of the feline myocardium to the arrhythmogenic effects of adrenaline was significantly less than that of halothane and not different that of isoflurane.
ISSN:0034-5288
1532-2661
DOI:10.1016/S0034-5288(96)90007-7