A New Approach Towards the Synthesis of 3-Amino-6-(hetero)arylpyridazines Based on Palladium Catalyzed Cross-coupling Reactions

The synthesis of 3-amino-6-(hetero)arylpyridazines via palladium catalyzed cross-coupling reactions (Suzuki, Stille) on 3-amino-6-chloropyridazine ( 1a) and 3-amino-6-iodopyridazine ( 1b) has been investigated. Comparison of the results shows that there is no need to start from 1b. An improved metho...

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Bibliographic Details
Published in:Tetrahedron 2000-03, Vol.56 (12), p.1777-1781
Main Authors: Maes, Bert U.W, Lemière, Guy L.F, Dommisse, Roger, Augustyns, Koen, Haemers, Achiel
Format: Article
Language:English
Subjects:
palladium and compounds
pyridazines
Stille reactions
Suzuki reactions
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Summary:The synthesis of 3-amino-6-(hetero)arylpyridazines via palladium catalyzed cross-coupling reactions (Suzuki, Stille) on 3-amino-6-chloropyridazine ( 1a) and 3-amino-6-iodopyridazine ( 1b) has been investigated. Comparison of the results shows that there is no need to start from 1b. An improved method for the synthesis of compound 1b from 1a is also described.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00083-1