A Simple Synthesis of Morphine-3,6-di-β- d-glucuronide

A convenient two-step synthesis of morphine-3,6-di-β- d-glucuronide in fair yield from morphine and methyl 2,3,4-tri- O-isobutyryl-1- O-trichloroacetimidoyl-α- d-glucopyranuronate is reported.

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Bibliographic Details
Published in:Tetrahedron 2000-09, Vol.56 (38), p.7591-7594
Main Authors: Brown, Richard T, Carter, Neil E, Mayalarp, Stephen P, Scheinmann, Feodor
Format: Article
Language:English
Subjects:
alkaloids
coupling reactions
glycosidation
stereoselection
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Description
Summary:A convenient two-step synthesis of morphine-3,6-di-β- d-glucuronide in fair yield from morphine and methyl 2,3,4-tri- O-isobutyryl-1- O-trichloroacetimidoyl-α- d-glucopyranuronate is reported.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00664-5