Reaction of 3-Methylamino-1,2-diols with Dihalomethanes. Synthesis of Chiral 4-Substituted 3-Methyltetrahydro-1,3-oxazin-5-ols

Enantiomerically pure 4,5-disubstituted 3-methyltetrahydro-1,3-oxazines have been obtained by reaction of 3-methylamino-1,2-diols with dichloromethane by regioselective differentiation of hydroxyl groups.

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Bibliographic Details
Published in:Tetrahedron 2000-10, Vol.56 (41), p.8173-8177
Main Authors: Hajji, Chakib, Testa, M a Luisa, Salud-Bea, Roberto de la, Zaballos-Garcı́a, Elena, Server-Carrió, Juan, Sepúlveda-Arques, José
Format: Article
Language:English
Subjects:
amino alcohols
dichloromethane
heterocycles
oxazines
oxazolidines
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Description
Summary:Enantiomerically pure 4,5-disubstituted 3-methyltetrahydro-1,3-oxazines have been obtained by reaction of 3-methylamino-1,2-diols with dichloromethane by regioselective differentiation of hydroxyl groups.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00744-4