Efficient synthesis of 3-aroylcinnolines from aryl methyl ketones

An efficient synthesis of 3-aroylcinnolines starting from the appropriate aryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid catalyzed cyclization in conc. sulfuric acid or polyphosphoric acid (PPA) led...

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Bibliographic Details
Published in:Tetrahedron 2001-02, Vol.57 (8), p.1609-1614
Main Authors: Al-Awadi, Nouria A, Elnagdi, Mohamed Hilmy, Ibrahim, Yehia A, Kaul, Kamini, Kumar, Ajith
Format: Article
Language:English
Subjects:
2-arylhydrazono-3-oxopropanal
aryl methyl ketones
cinnolines
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Summary:An efficient synthesis of 3-aroylcinnolines starting from the appropriate aryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid catalyzed cyclization in conc. sulfuric acid or polyphosphoric acid (PPA) led to the corresponding 3-aroylcinnolines. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)01141-8