Amide group assisted 3′-dephosphorylation of oligonucleotides synthesized on universal A-supports

(±)-3-Amino-1-(4,4′-dimethoxytriphenylmethyl)-2-propanediol was attached to succinylated alkylamino-controlled pore glass via the second amide bond. The resulting solid phase was acylated to give seven new universal solid supports, compatible with the preparation of all common types of oligodeoxyrib...

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Bibliographic Details
Published in:Tetrahedron 2001-06, Vol.57 (23), p.4977-4986
Main Authors: Azhayev, Alex V, Antopolsky, Maxim L
Format: Article
Language:English
Subjects:
amide group
oligonucleotides
solid supports
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Summary:(±)-3-Amino-1-(4,4′-dimethoxytriphenylmethyl)-2-propanediol was attached to succinylated alkylamino-controlled pore glass via the second amide bond. The resulting solid phase was acylated to give seven new universal solid supports, compatible with the preparation of all common types of oligodeoxyribonucleotides. These resins allow for fast elimination of the 3′-terminal phosphodiester or phosphorothioate function by ammonia in methanol at room temperature. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(01)00409-4