A new cytotoxic tetralone derivative from Humicola grisea, a filamentous fungus from wood in the southeastern lagoon of New Caledonia

Humicolone, a new phenolic tetralone in acetal form, was isolated, together with a known phenolic tetralone, from cultures of Humicola grisea Traaen, a hyphomycete taken from drifting wood in the southeastern lagoon of New Caledonia. Humicolone, determined from MTPA esters to have absolute configura...

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Bibliographic Details
Published in:Tetrahedron 2002-11, Vol.58 (45), p.9163-9167
Main Authors: Laurent, Dominique, Guella, Graziano, Mancini, Ines, Roquebert, Marie-France, Farinole, Fabrice, Pietra, Francesco
Format: Article
Language:English
Subjects:
cytotoxins
fungi
marine metabolites
terpenoids
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Summary:Humicolone, a new phenolic tetralone in acetal form, was isolated, together with a known phenolic tetralone, from cultures of Humicola grisea Traaen, a hyphomycete taken from drifting wood in the southeastern lagoon of New Caledonia. Humicolone, determined from MTPA esters to have absolute configuration 1′ R,3 S,4 S, showed cytotoxicity on KB cell lines, with IC 50 values between 1 and 5 ppm. Another unidentified filamentous fungus, also from drifting wood in a nearby New Caledonian marine area, gave phosphatidyl cholines and, unusually for fungi, a bisabolane sesquiterpene. Humicolone, a new phenolic tetralone in acetal form, was isolated from cultures of Humicola grisea Traaen and determined from MTPA esters to have absolute configuration 1′ R,3 S,4 S.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(02)01222-X