First synthesis of aza-calanolides—a new class of anti-HIV active compounds

First synthesis of (±)-aza-calanolides, starting from dimethoxy aniline, is achieved. These new compounds exhibited potent in vitro anti-HIV reverse transcriptase activity. Graphic

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Bibliographic Details
Published in:Tetrahedron 2003, Vol.59 (1), p.95-99
Main Authors: Madhava Sharma, G.V, Ilangovan, A, Narayanan, Ven L, Gurjar, Mukund K
Format: Article
Language:English
Subjects:
anti-HIV
aza-calanolide
calanolide
pyranocoumarin
quinolinone synthesis
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Description
Summary:First synthesis of (±)-aza-calanolides, starting from dimethoxy aniline, is achieved. These new compounds exhibited potent in vitro anti-HIV reverse transcriptase activity. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(02)01456-4