An improved synthesis of rhinocerotinoic acid

The stereoselective synthesis of E-rhinocerotinoic acid has been achieved in five steps from (−)-sclareol in an overall yield of 32%. This constitutes a significant improvement on the previous synthesis of this anti-inflammatory compound. The stereoselective synthesis of E-rhinocerotinoic acid ( 1 )...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2003-01, Vol.59 (2), p.165-173
Main Authors: Gray, Christopher A, Davies-Coleman, Michael T, Rivett, Douglas E.A
Format: Article
Language:English
Subjects:
diterpene
labdane
rhinocerotinoic acid
synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The stereoselective synthesis of E-rhinocerotinoic acid has been achieved in five steps from (−)-sclareol in an overall yield of 32%. This constitutes a significant improvement on the previous synthesis of this anti-inflammatory compound. The stereoselective synthesis of E-rhinocerotinoic acid ( 1 ) has been achieved in five steps from (−)-sclareol in an overall yield of 32%. This constitutes a significant improvement on the previous synthesis of this anti-inflammatory compound.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(02)01481-3