Synthesis of hapten–phosphoramidites from 2′-deoxyuridine

A total of 11 novel phosphoramidites, 3a– d , 4a– d and 14a– c were prepared from 2′-deoxyuridine functionalized at 5 and 6-position of the pyrimidine ring with hapten reporter groups, e.g. adamantane, carbazole, dansyl and dabsyl, suitable for use in immunodetection nucleic acid testing assays. Gra...

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Bibliographic Details
Published in:Tetrahedron 2003-07, Vol.59 (30), p.5749-5761
Main Authors: Adamczyk, Maciej, Akireddy, Srinivasa Rao, Mattingly, Phillip G, Reddy, Rajarathnam E
Format: Article
Language:English
Subjects:
2′-deoxyuridine
haptens
phosphoramidites
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Summary:A total of 11 novel phosphoramidites, 3a– d , 4a– d and 14a– c were prepared from 2′-deoxyuridine functionalized at 5 and 6-position of the pyrimidine ring with hapten reporter groups, e.g. adamantane, carbazole, dansyl and dabsyl, suitable for use in immunodetection nucleic acid testing assays. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(03)00875-5