Synthetic studies on tautomycin synthesis of Segment B

The synthesis of Segment B corresponding to the C26–C17 portion of tautomycin was accomplished by coupling reaction between the epoxide (Sub-segment B-1) and the dithiane (Sub-segment B-2). The degradation product of tautomycin corresponding to the C26–C19 portion was also synthesized from Sub-segme...

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Bibliographic Details
Published in:Tetrahedron 1997-04, Vol.53 (14), p.5083-5102
Main Authors: Tsuboi, Katsunori, Ichikawa, Yoshiyasu, Naganawa, Atsushi, Isobe, Minoru, Ubukata, Makoto, Isono, Kiyoshi
Format: Article
Language:English
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Summary:The synthesis of Segment B corresponding to the C26–C17 portion of tautomycin was accomplished by coupling reaction between the epoxide (Sub-segment B-1) and the dithiane (Sub-segment B-2). The degradation product of tautomycin corresponding to the C26–C19 portion was also synthesized from Sub-segment B-1. The synthesis of Segment B corresponding to the C26–C27 portion of tautomycin was accomplished by coupling reaction between Sub-segment B-1 and Sub-segment B-2.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)00228-7