Carbamate derived stable precursors for generating chiral azomethine ylids under mild conditions

We describe the evolution of stable azomethine ylid precursors which avoid the need for an aldehyde in the ylid generation step. tert-Butyl carbamate derivative ( 16) demonstrates comparable efficiency to the standard method of ylid generation and trapping, but permits use of milder conditions. Grap...

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Bibliographic Details
Published in:Tetrahedron 1997-09, Vol.53 (37), p.12671-12678
Main Authors: Alker, David, Harwood, Laurence M, Williams, C.Eleri
Format: Article
Language:English
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Summary:We describe the evolution of stable azomethine ylid precursors which avoid the need for an aldehyde in the ylid generation step. tert-Butyl carbamate derivative ( 16) demonstrates comparable efficiency to the standard method of ylid generation and trapping, but permits use of milder conditions. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)00788-6