Rhodium-catalysed hydroformylation and carbonylation of N-alkenyl-1,3-diaminopropanes

The rhodium catalysed reactions of N-alkenyl-1,3-diaminopropanes with H 2 CO usually give mixtures of diazabicycloalkanes and aminopropyl lactams. The chemo- and regioselectivity of these reactions are influenced by the choice of ligand and by the ratio of H 2 and CO in the gas mixture and in some c...

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Bibliographic Details
Published in:Tetrahedron 1997-12, Vol.53 (51), p.17449-17460
Main Authors: Bergmann, David J., Campi, Eva M., Jackson, W.Roy, McCubbin, Quentin J., Patti, Antonio F.
Format: Article
Language:English
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Summary:The rhodium catalysed reactions of N-alkenyl-1,3-diaminopropanes with H 2 CO usually give mixtures of diazabicycloalkanes and aminopropyl lactams. The chemo- and regioselectivity of these reactions are influenced by the choice of ligand and by the ratio of H 2 and CO in the gas mixture and in some cases formation of a single compound can be achieved. The chemo- and regioselectivity of rhodium-catalysed reactions of N-alkenylamines with H 2 CO is influenced by the ligand and the H 2 CO ratio. BIPHEPHOS gives the diazabicyclodecane (15) as the sole product from (9).
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)10193-4