Total synthesis of analogs of topostin B, a DNA topoisomerase I inhibitor. Part 4. Synthesis of topostin B-2 analogs

Analogs of topostin B-2, an inhibitor of mammalian DNA topoisomerase I, have been synthesized in a convenient manner. Analogs of topostin B-2, an inhibitor of mammalian DNA topoisomerase I, have been synthesized under the analogous synthetic route of the topostin B-1 analogs.

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Bibliographic Details
Published in:Tetrahedron 1998-01, Vol.54 (3), p.565-572
Main Authors: Fujiwara, Hideyasu, Egawa, Sadahiro, Terao, Yoshihiro, Aoyama, Toyohiko, Shioiri, Takayuki
Format: Article
Language:English
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Summary:Analogs of topostin B-2, an inhibitor of mammalian DNA topoisomerase I, have been synthesized in a convenient manner. Analogs of topostin B-2, an inhibitor of mammalian DNA topoisomerase I, have been synthesized under the analogous synthetic route of the topostin B-1 analogs.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)10316-7