Combinatorial synthesis of dihydropyridone libraries and their derivatives

Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives. The dihydropyridone scaffold was assembled via a solution phase Lewis acid catalyzed, herero-Diels-Alder reaction. Further modifications allow for the ra...

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Bibliographic Details
Published in:Tetrahedron 1998-04, Vol.54 (16), p.3983-3998
Main Authors: Creswell, Mark W., Bolton, Gary L., Hodges, John C., Meppen, Malte
Format: Article
Language:English
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Summary:Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives. The dihydropyridone scaffold was assembled via a solution phase Lewis acid catalyzed, herero-Diels-Alder reaction. Further modifications allow for the rapid generation of subsequent aminopiperidine and acyl-aminopiperidine libraries utilizing a library from library approach. Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(98)00130-6