Automated parallel synthesis of chalcone-based screening libraries

Using a variety of condensation and cyclization reactions, nine combinatorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 μM quantities. The ease with which a broad range of diversity can be fabricated around a single molecular motif using automated parallel so...

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Bibliographic Details
Published in:Tetrahedron 1998-04, Vol.54 (16), p.4085-4096
Main Authors: Powers, David G., Casebier, David S., Fokas, Demosthenes, Ryan, William J., Troth, Jonah R., Coffen, David L.
Format: Article
Language:English
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Summary:Using a variety of condensation and cyclization reactions, nine combinatorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 μM quantities. The ease with which a broad range of diversity can be fabricated around a single molecular motif using automated parallel solution phase synthesis has been demonstrated. Using a variety of condensation and cyclization reactions, nine combinatorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 μmole quantities.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(98)00137-9