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Grividomycins I, II and III, new antibiotics of the streptogramin class from Streptomyces sp. HIL Y-8240155

Three new antibiotics grividomycins I, II and III belonging to streptogramin class, have been isolated from a Streptomyces sp. HIL Y-8240155. The antibiotics are active against several resistant Gram positive bacteria. The structures of these compounds were elucidated mainly by HREIMS, GCMS and chir...

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Bibliographic Details
Published in:Tetrahedron 1998-06, Vol.54 (26), p.7625-7632
Main Authors: Mukhopadhyay, Triptikumar, Franco, C.M.M., Bhat, R.G., Sawant, S.N., Ganguli, B.N., Rupp, R.H., Fehlhaber, H.-W., Teetz, V.
Format: Article
Language:English
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Summary:Three new antibiotics grividomycins I, II and III belonging to streptogramin class, have been isolated from a Streptomyces sp. HIL Y-8240155. The antibiotics are active against several resistant Gram positive bacteria. The structures of these compounds were elucidated mainly by HREIMS, GCMS and chiral GC. Three new antibacterial compounds active against Gram +ve organisms were isolated; structure elucidation was carried out by HREIMS, GCMS and chiral GC.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(98)00395-0