A versatile procedure for the generation of nucleoside 5′-carboxylic acids using nucleoside oxidase

The nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5′-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale. Gr...

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Bibliographic Details
Published in:Tetrahedron 1998-07, Vol.54 (28), p.8171-8182
Main Authors: Mahmoudian, Mahmoud, Rudd, Brian A.M., Cox, Brian, Drake, Chris S., Hall, Richard M., Stead, Paul, Dawson, Michael J., Chandler, Malcolm, Livermore, David G., Turner, Nicholas J., Jenkins, Gareth
Format: Article
Language:English
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Summary:The nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5′-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(98)00456-6