On the metallation of 2-isopropylpyridine

2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA). Subsequent functionalization has been achieved with a wide range of electrophiles and good to excellent yields have been obtained. The action of other potassium or sodium bases has also...

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Bibliographic Details
Published in:Tetrahedron 1998-07, Vol.54 (30), p.8771-8782
Main Authors: Pasquinet, Eric, Rocca, Patrick, Marsais, Francis, Godard, Alain, Quéguiner, Guy
Format: Article
Language:English
Subjects:
deprotonation
metallation
potassium compounds
pyridine
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Summary:2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA). Subsequent functionalization has been achieved with a wide range of electrophiles and good to excellent yields have been obtained. The action of other potassium or sodium bases has also been investigated. 2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA) and other superbasic mixtures.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(98)00507-9