Pohlianins A, B and C, cyclic peptides from the laxes of Jatropha pohliana ssp. molissima

From the EtOAc extract of the latex of Jatropha pohliana (Euphorbiaceae), two cyclic heptapeptides, pohlianins A ( 1) and B ( 2) and one cyclic octapeptide, pohlianin C ( 3) were isolated by a multi-step chromatography procedure, including HPLC. Their structure were elucidated by chemical degradatio...

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Bibliographic Details
Published in:Tetrahedron 1999-09, Vol.55 (38), p.11495-11510
Main Authors: Auvin-Guette, Catherine, Baraguey, Carine, Blond, Alain, Xavier, Haroudo S., Pousset, Jean-Louis, Bodo, Bernard
Format: Article
Language:English
Subjects:
cyclic peptides
Jatropha
molecular modeling
nmr
β-bulge
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Summary:From the EtOAc extract of the latex of Jatropha pohliana (Euphorbiaceae), two cyclic heptapeptides, pohlianins A ( 1) and B ( 2) and one cyclic octapeptide, pohlianin C ( 3) were isolated by a multi-step chromatography procedure, including HPLC. Their structure were elucidated by chemical degradation, mass spectrometry, homonuclear and heteronuclear NMR experiments. Conformational analysis of these peptides was made by using NMR experiments and distance geometry calculations. Their antimalarial activities were examined. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(99)00660-2