The parallel synthesis of peptide based phosphine ligands

Chemistry is reported that allows for the synthesis and screening of phosphine ligands by standard combinatorial technology. To demonstrate the method, libraries of phosphine containing peptides were synthesized. Rhodium was complexed to the phosphine ligands while they were attached to the synthesi...

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Bibliographic Details
Published in:Tetrahedron 1999-09, Vol.55 (39), p.11609-11618
Main Authors: Gilbertson, Scott R., Wang, Xifang
Format: Article
Language:English
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Summary:Chemistry is reported that allows for the synthesis and screening of phosphine ligands by standard combinatorial technology. To demonstrate the method, libraries of phosphine containing peptides were synthesized. Rhodium was complexed to the phosphine ligands while they were attached to the synthesis support. Each member of the library was screened for its ability to catalyze the asymmetric hydrogenation of enamides. Libraries of phosphine containing peptides are synthesized and screened for their ability to catalyze asymmetric hydrogenation. The selectivity of members of the library were determined with the catalysts attached to the solid support and in solution.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(99)00682-1