Efficient chemical synthesis of a pyrimidine (6–4) pyrimidone photoproduct analog and its properties

We synthesized an analog of a pyrimidine (6–4) pyrimidone photoproduct with a formacetal linkage instead of the phosphodiester in the (6–4) photoproduct, and investigated the interaction between a monoclonal antibody specific to the natural (6–4) photoproduct and a DNA containing the photoproduct an...

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Bibliographic Details
Published in:Tetrahedron letters 2000-03, Vol.41 (13), p.2175-2179
Main Authors: Satou, Kousuke, Komatsu, Yasuo, Torizawa, Takuya, Kato, Koichi, Shimada, Ichio, Nikaido, Osamu, Ohtsuka, Eiko
Format: Article
Language:English
Subjects:
antibodies
antigens
nucleic acid analogs
nucleic acids
photochemistry
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Summary:We synthesized an analog of a pyrimidine (6–4) pyrimidone photoproduct with a formacetal linkage instead of the phosphodiester in the (6–4) photoproduct, and investigated the interaction between a monoclonal antibody specific to the natural (6–4) photoproduct and a DNA containing the photoproduct analog.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00127-1