Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol kinase

A nonmevalonate pathway intermediate, 4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol, is transformed to its 2-phospho-derivative in the presence of ATP by a novel Escherichia coli enzyme, 4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol kinase.

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Bibliographic Details
Published in:Tetrahedron letters 2000-04, Vol.41 (16), p.2925-2928
Main Authors: Kuzuyama, Tomohisa, Takagi, Motoki, Kaneda, Kazuhide, Watanabe, Hiroyuki, Dairi, Tohru, Seto, Haruo
Format: Article
Language:English
Subjects:
2-phospho-4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol
4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol
4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol kinase
isopentenyl diphosphate
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Summary:A nonmevalonate pathway intermediate, 4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol, is transformed to its 2-phospho-derivative in the presence of ATP by a novel Escherichia coli enzyme, 4-(cytidine 5′-diphospho)-2- C-methyl- d-erythritol kinase.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00295-1