Symmetrically-substituted decalin-based scaffolds

The synthesis of a chiral scaffold was achieved by coupling a decalintriol platform with a NH-Boc protected α-ethylenic γ-amino acid. The two side chains of this molecule strongly self-associate through intramolecular hydrogen bonding involving the NH-Boc residues.

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Bibliographic Details
Published in:Tetrahedron letters 2000-04, Vol.41 (16), p.2907-2910
Main Authors: Plyta, Zoi F, Heller, Eberhard, Dumas, Françoise, Miet, Christine, Mahuteau, Jacqueline, d'Angelo, Jean, Caturla, Juan, Tran Huu Dau, Marie-Elise
Format: Article
Language:English
Subjects:
conformation
hydrogen bonding
molecular modeling
molecular recognition
NMR
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Description
Summary:The synthesis of a chiral scaffold was achieved by coupling a decalintriol platform with a NH-Boc protected α-ethylenic γ-amino acid. The two side chains of this molecule strongly self-associate through intramolecular hydrogen bonding involving the NH-Boc residues.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00311-7